Studies on Nucleic Acid Antagonists. VI. Synthesis of 1, 4, 6-Triazain-denes(5H-Pyrrolo[3, 2-d]pyrimidines)

Abstract

Two methods of synthesizing 1, 4, 6-triazaindene, which was isosteric to purine and to indole were described. The first method involves the ring-closure of 5-acylamido-6-methylpyrimidines. The second method involves the Claisen reaction of 5-nitro-6-methylpyrimidines followed by reductive condensation.