Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis of 5-Substituted Pyrimidine Nucleosides
Kin-ichi ImaiMikio Honjo
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1965 Volume 13 Issue 1 Pages 7-16

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Abstract
Uridine-5-carboxaldehyde (I), uridien-5-carboxylic acid (II), and 1-(β-D-ribofuranosyluronic acid) uracil-5-carboxaldehyde (III) were isolated and characterized form the reaction products obtained after catalytic oxidation of uridine-5-methanol (IV). Five aldehyde hydrazone derivatives of I and III were synthesized. Catalytic oxidation of several pyrimidine nucleosides gave the corresponding uronic acid derivatives. The ease of the oxidation of these compounds was found different, depending upon the base moieties.
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© The Pharmaceutical Society of Japan
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