Biopharmaceutical Studies on Factors Affecting Rate of Absorption of Drugs. I. Absorption of Salicylamide in Micellar Solution.

抄録

1) The model of absorption of drug in micellar solution from the intestine is proposed. According to this model, the relationship between concentration of the surfactant and absorption rate constant of the drug was derived. The calculated values of the absorption rate constants from the equation were compared with the experimentally observed values.2) The determination of absorption rate constant was carried out by the perfusion of salicylamide solutions containing polysorbate-80 in various concentrations through the rat small intestine in situ. 3) The experimental results indicate that there is a quite agreement between the observed value and the calculated value.