As a part of studies on the Janovsky reaction of nitropyridines, 3-substituted-5-nitropyridines such as 2-hydrazino-5-nitronicotinonitrile (I), 5-nitronicotinonitrile (II), 5-nitronicotinic acid (III), ethyl 5-nitronicotinate (VIII), 5-nitronicotinamide (IX), and 3-amino-5-nitropyridine (XI) were prepared. Some of their N-oxides such as ethyl 5-nitronicotinate 1-oxide (VII), 5-nitronicotinic acid 1-oxide (XII) and 5-nitronicotinonitrile 1-oxide (XV) were also prepared.
