Author's Organization:Central Research Laboratory, Daiichi Seiyaku Co., Ltd. Central Research Laboratory, Daiichi Seiyaku Co., Ltd. Central Research Laboratory, Daiichi Seiyaku Co., Ltd. Central Research Laboratory, Daiichi Seiyaku Co., Ltd. Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
A novel synthesis of pantethine (VIII) from 3-aminopropionitrile (I) was established through the intermediate formation of thiazoline derivative (IV) followed by hydrolysis thereof.