Studies on the Metabolism of Sulfadimethoxine. I. On the Excreted substance in the Human Urine after Oral Administration of Sulfadimethoxine

Abstract

Metabolic products of sulfadimethoxine excreted in human urine were examined and three metabolites were separated. Unchanged sulfadimethoxine and N⁴-acetylsulfadimethoxine were confirmed by paper chromatography and electrophoresis. And, the other one was sulfadimethoxine-N-glucuronide, and the methyl acetyl derivative of the glucuronide was confirmed sulfadimethoxine-N¹-methyl-(tri-O-acetyl-β-D-glucopyranosid)uronate-N⁴-acetate. Sulfadimethoxine-N-glucuronide found in human urine was decided to be sulfadimethoxine-N¹-β-D-glucopyranoside or its lactone form.