Synthetic Studies on η-Pyrromycinone II. Synthesis of Methyl 2-Ethyl-5-Hydroxy-1-naphthoate

Abstract

As a part of the investigation on the synthesis of η-pyrromycinone (I), methyl 2-ethyl-5-hydroxy-1-naphthoate (II, R=OH) was synthesized by a series of reactions indicated in Chart 1 and 2. The stereochemistries of the tetralone derivatives obtained as preparative intermediates were discussed from the chemical and nuclear magnetic spectral evidences.