Abstract
It is very convenient to use methylbarbital as substrate in order to check the pheno-barbital-effect, and on the other hand, meperidine is useful to measure the degree of inhibition in the enzyme activity by narcotics such as morphine etc. It was recognized that the repeated administration of morphine to rats caused gradually depression of detoxicating enzyme activity in demethylation of narcotics, but did not affect on the incorporation of 14C-amino acids into rat liver protein.
