Abstract
N-(L-β-Aspartyl)-2-acetamido-2-deoxy-β-D-glucosylamine has been prepared by the condensation of N-benzyloxycarbonyl-L-aspartic acid α-benzyl ester with 2-acetamido-2-deoxy-3, 4, 6-tri-O-acetyl-β-D-glucosylamine in the presence of dicyclohexylcarbodiimide followed by hydrogenolysis and de-O-acetylation on the resulting 1-(α-benzyl N-benzyloxy-carbonyl-L-β-aspartamido)-2-acetamido-1, 2-dideoxy-3, 4, 6-tri-O-acetyl-β-D-glucose to remove the protecting groups. N-(L-β-Aspartyl)-2-acetamido-2-deoxy-β-D-glucosylamine and N-(L-γ-glutamyl)-2-acetamido-2-deoxy-β-D-glucosylamine have been prepared by the same method as for β-aspartylglycopeptide.
