Studies on Phosphorylation. II. Phosphorylation of Nucleosides with Organic Amine Salts on Phosphoric Acid.

抄録

Inosine 5′-phosphate has been synthesized by heating isopropylidene-inosine with mono (or di)(tri-n-butylammonium)-, mono (triethylammonium)-, or monoanilinium phosphate in dimethylformamide followed by removal of the protecting group. Similarly, from isopropylidene-adenosine, -guanosine, -cytidine and -uridine, the corresponding 5′-nucleotides were obtained and rom thymidine, its mono- and di-phosphate. Furthermore, inosine 5′-phosphate and 5′-diphosphate were prepared by heating isopropylidene inosine with tri-n-butylammonium-pyrophosphate or -polyphosphate.