Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Synthesis of Coumarin Derivatives. XIX. On te Preparation of (2-Methyloxazolo) coumarin-3-carboxylic Acid Derivatives
Haruo SaikachiMasataka Ichikawa
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1966 Volume 14 Issue 12 Pages 1350-1354

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Abstract
Ethyl (2-methyloxazolo) coumarin-3-carboxylates were hydrolyzed with 2% aq.sodium hydroxide solution to give the corresponding carboxylic acids, respectively. The acid chlorides prepared from the carboxylic acids were condensed with secondary amines to give the corresponding 3-carbamoyl derivatives in good yield, respectively. Diethylamine, pyrrolidine, piperidine, and morpholine were used as secondary amines.
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© The Pharmaceutical Society of Japan
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