Studies on Opically Active Amino Acids. VII. Stereoselective Synthesis of l-Norephedrine Hydrochloride from D-Phenylalanine

Abstract

Stereoselective synthesis of l-norephedrine hydrochloride (XI) was investigated starting from D-phenylalanine (D-I), by making use of the comparable configuration at the α-carbon in D-I with the asymmetric center bearing the amino group in XI. The synthetic route is shown in Chart 2.