Kinetics of the Nucleophilic Displacement Reactions of Halogenopyridazine 1-Oxides

Abstract

Reaction rates of 3-, 4-, 5-, and 6-chloropyridazine 1-oxides and other halogenopyridazine 1-oxides with piperidine and with sodium ethoxide were measured. The rates and derived parameters were compared. The rate order of position reactivity was 5>3>6>4.