Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Syntheses of Pyridazine Derivatives. IV. Halogenopyridazine 1-Oxides
Shigeru Sako
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1966 Volume 14 Issue 3 Pages 303-306

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Abstract
N-oxidation of 5-amino-3, 4-dichloropyridazine and 4-amino-3, 5-dichloropyridazine gave their 1-oxides. The amino groups on 3-, 4-, 5-, and 6-positions of pyridazine 1-oxide were substituted with chlorine or bromine by diazotization, but yield of 3-bromopyridazine 1-oxide was poor. 5-Amino-3, 4-dichloropyridazine 1-oxide is usable as the starting material for the preparation of 5-substituted pyridazine 1-oxides.
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© The Pharmaceutical Society of Japan
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