Studies on Tertiary Amine Oxides. XXVI. Nitration of 6-Substituted Quinoline 1-Oxides.

抄録

Nitrations of 6-chloro-, 6-bromo-, 6-methyl-, 6-methoxy-quinoline and quinoline 1-oxides with potassium nitrate in sulfuric acid were re-examined by varying the concentration of the acid and the reaction temperatures. The orientation of reaction was found to be more markedly dependent upon the concentration of sulfuric acid rather than the reaction temperature ; generally, the activity of the 4-position toward nitration became most remarkable by use of 75∼85% sulfuric acid.