Synthesis of Antibiotics. I. Synthesis of N-Substituted Compounds of Monochloroacylamide and Their Antitrichophyton Effect

Abstract

Thirteen kinds of monohalogenoacyl substituted aromatic derivatives were synthesized and tested their antitrichophyton effect. On anilide, Cl substitution of p-position is 30 times as strong as that of o-position, and Cl substitution is 33 times as strong as Br substitution. The double bond of acyl group of monohalogenoacyl substituted aromatic amide derivatives did not show strong fungical effect, and there was no difference of fungical effect between cis and trans.