Studies on the Pyrimidine Derivatives and Related Compounds. XL. Reaction of 3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium Salts with Diethyl Benzoylphosphonate

Abstract

Reaction of 3-benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium chloride (V) with diethyl benzoylphosphonate (VII) was studied successively as an analogue of thiamine. It is also appeared in this case that a novel reaction took place accompanied by the ring expansion from thiazole to 1, 4-thizzine ring.