Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Thioamides. IV. Extension of the Cyclodesulfurization Reaction to Synthesize 1-Substituted and 1, 3-Disubstituted-3, 4-dihydro-9H-pyrido [3, 4-b] indole Derivatives
/ 山田 俊一Shun-ichi Yamada
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1966 年 14 巻 8 号 p. 856-861

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抄録
Three new N-[2-(3-indolyl)ethy1] thioamides (IIa∼c) and N-(methylthiocarbony1) tryptophan methyl ester (III) were conveniently prepared according to our general procedure of synthesizing thioamides. The cyclodesulfurization of IIa∼c was successfully accomplished in high yield to the corresponding 1-subsituted-3, 4-dihydro-9H-pyrido[3, 4-b]-indole derivatives (IVa∼c). In addition, III was cyclized to give a mixture of both 1-methy1-3, 4-dihydro-9H-pyrido[3, 4-b]indole-3-caroxylic acid (Vb), and its methyl ester (Va) in excellent yield.
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© The Pharmaceutical Society of Japan
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