Studies on Synthetic Sweetening Agents. VIII. Cyclohexylamine, a Metabolite of Sodium Cyclamate

Abstract

The urinary metabolic product of CHS-Na in human, rabbit, and dog was studied. As a metabolite of CHS-Na, cyclohexylamine was found in the urine from human and dog which were received CHS-Na orally. From human urine, the metabolite was isolated as a benzoyl derivative and was quantitatively estimated. In rabbit, however, any metabolite of CHS-Na was not found in our experiment.