Radioisotopic Studies on Percutaneous Absorption. I. Absorption of Water-soluble Substances from Hydrophilic and Absorption Ointments through Mouse Skin.

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The percutaneous absorbability of water-soluble substances from emulsion-type ointments was demonstrated by measuring the absorption of radioactivity after application of hydrophilic and absorption ointments containing Na¹³¹I, ⁵⁹Fe-EDTA, ⁵⁹Fe-tiron or ²²NaCl to hairclipped mouse skin. The absorption of lipid-soluble ⁵⁹Fe-cupferron and ⁵⁹Fe-carbamate from these vehicles was quite small. The large promoting effect of polyethylene oleyl ether on the percutaneous absorption of ⁵⁹Fe-EDTA from polyethylene glycol 1500 through mouse skin suggested some important contribution of surface-active agents to the percutaneous absorption of water-soluble substances from hydrophilic and absorption ointments.