Abstract
The reactions of 2, 2'-anhydrouridine (I) with hydrogen sulfide (Reaction A) and of I, 3', 5'-di-O-benzoyl-2, 2'-anhydrouridine (III) and 1-(3', 5'-di-O-benzoyl-2'-methanesulfonyl-β-D-arabinofuranosyl) uracil (V) with thiobenzoate or xanthogenate nucleophiles (Reactions B), were investigated with the purpose of introducing thiol substituents at the 2'-position. The Reaction A afforded 1-β-D-arabinofuranosyl-2-thiouracil (II) as only sulfur containing product and the Reactions B gave no sulfur containing product but resulted in a partial liberation of uracil.
