Abstract
The effect of terephthalic acid on the blood level of sulfaethylthiadiazole in the rabbit was examined. About twice increase of the biologic half-life of sulfaethylthiadiazole in the range of 50 to 150mg./kg. of terephthalic acid was shown at the simultaneous oral administration. No marked effect was shown by parenteral administration of terephthalic acid. The acute toxicity following simultaneous intraperitoneal administration was investigated in the mouse. The increase of the acute toxicity was not observed significantly judging from LD50 determined by the single administration of sulfaethylthiadiazole and of terephthalic acid.
