Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Passage of α-Chymotrypsin across the Intestine.
Hiroshi MoriyaChiaki MoriwakiSetsuko AkimotoKeiko YamaguchiMasanori Iwadare
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1967 Volume 15 Issue 11 Pages 1662-1668

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Abstract
^<131>I-labelled α-chymotrypsin was administered into the ligated intestine of adult rats, and 131I distribution was studied. Differences were found in the distribution in the kidney from the control experiment of 131I-KI administration in the same way. Furthermore, 131I-bound protein was surely observed in the serum after the intraintestinal administration of 131I-labelled α-chymotrypsin was comparatively stable in natural human intestinal and gastric juices under the addition of 0.033M Ca ion, but without Ca ion, it was rapidly degraded and lost its esterase activity with both juices. In in vitro experiment with the sac of everted intestine of rats, it was found that chymotrypsin was transferred from the mucosal to the serosal side with its esterase activity. From these experimental results, the possibility of the transfer of α-chymotrypsin across the intestine was discussed.
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© The Pharmaceutical Society of Japan
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