Abstract
Three series of PAS derivatives, alkyl, ω-hydroxyalkyl, and ω-phenylalkyl esters, were synthesized systematically and their evaluations were made with testing their tuberculostatic activities and with measuring their physico-chemical characteristics, such as partition coefficients and protein binding ratio that might considerably influence biological effects in animal body. It is recognized that these derivatives may extensively improve the defects of the parent compound. It is also demonstrated that the substituents on the end of the alkyl chain and the length of the alkyl chain of these compounds considerably influence on their antitubercular activities and physico-chemical properties.
