Studies on Peptides. XII.Synthesis of the Decapeptide corresponding to the C-Terminal Portion of β-Melanocyte-stimulating Hormone

Abstract

Synthesis of the decapeptide, histidylphenylalanylarginyltryptophylglycylserylprolylprolyl-lysylaspartic acid (I) corresponding to the C-terminal portion of β-melanocyte-stimulating hormones (β-MSH) from pig, sheep, beef, monkey and human was described. I was obtained by deformylation of histidylphenylalanylarginyltryptophylglycylserylprolylprolyl -N^ε- formyllysylaspartic acid (II) with aqueous hydrazine. The MSH activity of I and II was examined in vitro. It was found that I and II exhibited the activity, 2.4×10⁶ and 1.0×10⁶ MSH U/g. respectively.