抄録
The synthesis of optically active hexahydro-1H-pyrrolizin-1-one(I)from L-proline and the resolution of hexahydro-1(5H)-indolizinone(II), hexahydro-8(5H)-indolizinone(III), and hexahydro-2H-quinolizin-1(6H)-one(IV) by means of d-3-bromo-8-camphorsulfonic acid and d-10-camphorsulfonic acid were described. Their rate constants and half-times for racemization were determined under various conditions, at 20°, and in aqueous ethanol I was found to be racemized very rapidly, while in hydrochloric acid, no racemization was observed.
