Abstract
The hog pancreatic kallikrein was labelled with radioactive iodine (131I) and was administered to rats in the tied loop of the jejunum. Relatively high distribution of radioactivity was found in the kidney and the liver and the existence of the 131I-labelled macromolecules in serum was also observed after the intraintestinal administration of 131I-kallikrein. The sac of everted jejunum was incubated in the Krebs-Ringer bicarbonate buffer containing 131-kallikrein and itwas observed that the radioactive macromolecule having the vasodilator activity was transferred to the serosal side from the mucosal side. From these results, the possibility of the intestinal absorption of pancreatic kallikrein was discussed.
