Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Pharmaceutical Potentiation of Drugs. III. Antagonistic Effects of PABA on Antitubercular Activities of PAS Derivatives.
掛見 喜一郎瀬崎 仁北沢 式文
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1967 年 15 巻 7 号 p. 925-931

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Antagonistic effects of PABA on the tuberculostatic activities of synthesized ω-substituted alkyl esters of PAS were examined. It was found that these derivatives were competitively antagonized and their inhibition indices decreased to 0.1 or 0.01 from one of the parent compound, and the correlation between partition coefficients and inhibition indices of these derivatives seems to exist.
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© The Pharmaceutical Society of Japan
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