The C-Alkylaminomethylation of Pyridazinol N-Oxides. III. The Mannich Reaction of 5-Pyridazinol 1-Oxide
1968 年 16 巻 1 号 p. 142-147
詳細
1968 年 16 巻 1 号 p. 142-147
5-Pyridazinol 1-oxide was synthesized from 5-methoxypyridazine 1-oxide which was obtained from 3, 4-dichloro-5-methoxypyridazine 1-oxide. The Mannich reaction of 5-pyridazinol 1-oxide using 37% formalin and piperidine gave 6-piperidinomethyl-5-pyridazinol 1-oxide in 40% yield. Treatment of 5-pyridazinol 1-oxide with excess amounts of the reagents gave 4, 6-di (piperidinomethyl)-5-pyridazinol 1-oxide in 56% yield. The alkylaminomethylated positions in these Mannich bases were determined by NMR spectroscopy.
