Abstract
During the course of the studies for synthesis of II, the Ullmann reaction product of 8-bromoarmepavine, Bischler-Napieralski reaction of amide XI was carried out. Characterization of the product was effected by metallic sodium-liquid ammonia fission reaction. It was found that the isoquinoline ring-closure of such an amide formulated as XVIII occurred onto both o-and p-positions to the phenoxyl grouping, that is, the direction of the ring-closure was unexpectedly affected by substituent borne on 4-position of the phenoxyl grouping.
