Acylindoles. VIII. New Procedures for 1-Heteroaroylindole-3-acetic Acid Derivatives

抄録

1-Heteroaroyl-2-methylindole-3-acetic acid derivatives are prepared by reacting the corresponding N¹-heteroaroylphenylhydrazine derivatives with levulinic acid. And these indole derivatives are also prepared by some other procedures. In one of these compounds, 1-nicotinoyl-2-methyl-5-methoxyindole-3-acetic acid, the existence of its dimorph is suggested by the infrared spectrum. The indole derivatives show a remarkable experimental anti-inflammatory activity having extremely low toxicity.