抄録
4-Hydroxy-1-(β-D-ribofuranosyl)-1H-imidazo [4, 5-c] pyridine (3-deazainosine, XIV) was prepared by use of the corresponding 4-chloro derivative (IX) as a key intermediate. It was found that the reaction of IX with hydrazine afforded either 1-(β-D-ribofuranosyl)-1H-imidazo [4, 5-c] pyridine (XIII) by de-chlorination or 4-hydrazino-1-(β-D-ribofuranosyl)-1H-imidazo [4, 5-c] pyridine (X) depending upon conditions employed. Improved synthesis of IX was achieved by an adaptation of Yamaoka, Matsuda and Aso's method. In addition to X and XIV, a number of other 4-substituted ribonucleosides and nucleotides having imidazo [4, 5-c] pyridine (3-deazapurine) ring system, such as XII, XV, XVI and XVII were prepared.
