Abstract
A convenient synthesis of 6-ethyl-1-naphthol (I) and its conversion into 4-bromo-6-ethyl-1-naphthol (VI) are described. Chromium trioxide oxidation of 6-ethyltetralin gave predominantly 6-ethyl-1-tetralone (IX), which was dehydrogenated with palladized charcoal to I. Bromination of I afforded VI, a starting material in the synthesis of bisanhydrodaunomycinone (V). Structuers of VI and IX were confirmed by alternative syntheses as shown in Chart 3.
