Studies on the Method of Size Reduction of Medicinal Compounds. III. Size Reduction of Griseofulvin by Solvation and Desolvation Method using Chloroform. (3)

Abstract

In order to find the limit of size reduction by the method of solvation and desolvation, the effect of repeated solvation and desolvation of CHCl₃ on the specific surface area of griseofulvin particles was investigated by the BET gas adsorption method. It was found that the antibiotics was effectively pulverized by a single application of the method. The applicability was also tested with several substances forming solvates and hydrates and the specific surface areas were all found to be 2-3m²/g, unless a solution was formed during the desolvation process. The heat of solvation of griseofulving with CHCl₃ and the heat of activation of the desolvation reaction were estimated to be 6.4±0.5 and 20±1 kcal/mole by the differential scanning calorimetry and gas evolution analysis.