Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Metabolism of Drugs. IX. On the Excreted Substances in the Human Urine after Oral Administration of Sulfamethomidine
MICHIHIRO UEDANORIHIKO MURAKAMIKAZUKO FURUKIHARUMI ATSUMURA
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1968 Volume 16 Issue 2 Pages 352-356

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Abstract
Metabolic products of sulfamethomidine excreted in human urine were examined by paper chromatography and three metabolites were detected. Unchanged sulfamethomidine and N4-acetylsulfamethomidine were confirmed by paper chromatography. And, the other one was isolated and identified to be sodium sulfamethomidine-N1-D-glucopyranosiduronate containing 1 mole of water of crystallization by the comparison of infrared and ultraviolet spectrographic data, and Rf values with the synthetic specimen.
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© The Pharmaceutical Society of Japan
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