Abstract
The present paper has established the kinetics and mechanisms for the general aicd-base catalysed hydrolysis of chlorothiazide (I) over the pH range 0.08-9.96 at 87.5°, which decomposes to 4-amino-6-chloro-m-benzenedisulfonamide (IV) via parallel consecutive firstorder reaction in aqueous solution : one leading to the formation of N-(2-amino-4-chloro-5-sulfamoylphenylsulfonyl) formamide (II) in aqueous alkali, and the other leading to the formation of 5-chloro-2, 4-disulfamoylformanilide (III) in acidic media.
