Author's Organization：Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo
Decarboxylation of 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid derivatives, I, II, III, IV and IV hydrochloride, in acetophenone and benzaldehyde as solvents, was examined. It was found that in the case of IV hydrochloride, 4-substituted isoquinoline derivatives were formed in moderate yield according to the solvent used.
