Abstract
The effect of 14 thiocyanato derivatives of purines and their ribonucleosides were compared with the effects of 6-purinethiol and 2-amino-6-purinethiol against transplanted sarcoma (NF-Sarcoma) in mice and the correlation was noted between antitumor activities and substituting position of thiocyanato group and other substituent groups on the purine ring. 6-Thiocyanatopurine, 2-amino-6-thiocyanatopurines and their ribonucleosides were demonstrated as the most active of the thiocyanato derivatives.
