Abstract
Cyclization of the dialdehyde, obtained by periodate oxidation of tetra-N-acetyl-kanamycin, with nitromethane, followed by reduction and hydrazinolysis gave the titled compounds. Structural assignment of these derivatives was accomplished by NMR spectroscopy and degradation to the respective component sugars. Direct treatment of 3'-nitro-3'-deoxyderivative with hydrazine gave, via decomposition of the nitro sugar portion, O-a-D-3-amino-3-deoxyglucopyranosyl (1→6)-2-deoxystreptamine.
