Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Medicinal Chemical Studies on Antiplasmin Drugs. II. Separation of Stereoisomers of 4-Aminomethylcyclohexanecarboxylic Acid and Assignment of Their Configuration
TAKEO NAITO, ATSUJI OKANO, SHIZUO KADOYA, TOSAKU MIKI, MASATO INAOKA, REIMEI MOROI, MASAO SHIMIZU
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1968 Volume 16 Issue 4 Pages 728-733

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Abstract
The stereoisomers of 4-aminomethylcyclohexanecarboxylic acid (I) and (II) were completely separated from their mixture, respectively, and it is proved that lowermelting isomer has the cis-configuration and higher-melting isomer whose antiplasmin activity is much potent has the trans-configuration.
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© The Pharmaceutical Society of Japan
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