Effect of Conformation of Molecules on Molecular Interaction. II. Nicotinamides and Pyridine Esters

Abstract

In a series of solubility studies of pyridine derivatives with 8-methoxycaffeine in aqueous solution, an extent of molecular interaction of N, N-dimethylnicotinamide (I) was found to be much less than those of unsubstituted and N-monomethylnicotinamide. Degree of complexation of 3-acetoxypyridine (II) was revealed to be much less than that of methyl nicotinate. Reduced complexing tendencies of I and II were attributed to nonplanar structures of these compounds in solution.