Studies on Digitalis Glycosides. Gitoxin Acetates. 2. Deacetylation of Pentaacetylgitoxin with Liver and Heart Homogenates

Abstract

Incubation of pentaacetylgitoxin (I) with liver and heart homogenates of rabbits easily caused the fission of acetyl groups in the terminal sugar moiety and gave 3', 3", 16-triacetylgitoxin (IIc) as a main product, respectively, accompanied with small quantities of several partial acetates and gitoxin (IIj). IIc was the intermediate in hydrolysis of I to IIj with dilute alkali.