Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Chemistry of Diborane and Sodium Borohydride. VI. The Reaction of Amides with Sodium Borohydride
菊川 靖雄池上 四郎山田 俊一
著者情報
ジャーナル フリー

1969 年 17 巻 1 号 p. 98-104

詳細
抄録
The reactions of primary, secondary and tertiary amides with sodium borohydride in refluxing pyridine were examined. Tertiary amides were reduced to the corresponding amines in moderate yield, in case of secondary amide no reaction occured and the starting amide was recovered, primary amides, on the contrary, were dehydrated to nitriles. Especially, when nicotinamide was used, the reduction of pyridine nucleus accompanied by dehydration occured to give 1, 4, 5, 6-tetrahydronicotinonitrile.
著者関連情報
© The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top