Microbial Transformation of Steroid. I. Microbiological Hydroxylation of Diosgenin

抄録

Microbial oxidation of diosgenin with Cunninghamella blakesleeana gave 7β-hydroxydiosgenin, 7β, 12β-dihydroxydiosgenin, and 7β, 11α-dihydroxydisogenin. The former two compounds were confirmed by their synthesis from 7-oxodiosgenin and 7, 12-dioxodiosgenin (=7-oxogentrogenin) respectively with lithium aluminum hydride.