Abstract
The effect of anti-inflammatory drugs on leucocyte migration and vascular permeability during acute inflammation was examined in lathyritic rats by carboxymethylcellulose pouch method. The above mentioned two unit reactions, especially leucocyte migration, in inflammation locus were promoted in lathyritic rats compared to normal rats. Inhibition pattern of protein exudation showed significant difference between normal and lathyritic groups in case of steroidal anti-inflammatory drugs. Forty percent inhibition in lathyritic rats was observed 3 hr after the injection of corticosteroids, while in normal rats there was no inhibition until 6 hr. There was no marked difference between these two groups in non-steroidal antiinflammatory drugs. The inhibitory effect of steroidal and non-steroidal anti-inflammatory drugs on leucocyte migration was almost the same as in the normal rats or slightly stimulated in lathyritic rats.
