Abstract
On the way of the study to improve the in vivo antibacterial activity of nitrofuran compounds, it was found that the some N-oxide derivatives of (5-nitro-2-furyl) vinyl heterocycles had the superior in vivo activity to the corresponding original compounds. To clarify whether such tendency was observed in general, thirteen (5-nitro-2-furyl) vinyl heterocycles and their N-oxide derivatives were co mpared on their oral protective effects in mice and additionally on the in vitro antibacterial activities and the plasma levels in rats. It was generally observed that the N-oxide derivatives were superior to the corresponding original compounds in the protective effects. Such superiority seemed to be partially attributed to the increase of the in vitro antibacterial activities and the plasma levels of the N-oxide derivatives.
