Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Reaction of Pyridazine 1-Oxide with Grignard Reagent
GENZO OKUSAMICHIKO KUMAGAITAKANOBU ITAI
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1969 Volume 17 Issue 12 Pages 2502-2506

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Abstract
A reaction of pyridazine 1-oxide with Grignard reagents prepared from bromobenzene, p-bromotoluene, o-bromotoluene, m-bromotoluene, p-bromoanisol and o-bromoanisol, gave the corresponding 1-aryl-trans-1-butene-3-yne (III) in about 30% yields. These structures were determined by in frared and nuclear magnetic resonance spectroscopy.
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© The Pharmaceutical Society of Japan
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