1969 Volume 17 Issue 3 Pages 510-514
First, N-oxidation of trifluoromethylated pyridines was carried out. The three isomers of trifluoromethylpyridine were successfully N-oxidized using acetic acid and hydrogen peroxide, but with 2, 4- and 2, 6-bis (trifluoromethyl) isomers of bis (trifluoromethyl) pyridine, N-oxidation was successful only when trifluoroacetic acid and hydrogen peroxide were used. Next, the reaction of the N-oxides of the three isomers of (trifluoromethyl) pyridine with acetic anhydride and their Reissert reaction were carried out ; the effect of trifluoromethyl group was very marked. The success in the Reissert reaction with pyridine series is only second to that with 4-chloropyridine 1-oxide.