Abstract
Relations between the properties of pyridoxine and pyridoxine 3, 4-diacylates and the changes of vehicles in percutaneous absorption were studied. a) Depilated skin : PIN is absorbed more rapidly than PIN-HCL. While, PIN showed a rapid change in blood level, PIN-DK, -DIK gave high blood level 24 hours after the application of the drugs. b) Normal skin : The normal skin cases for PIN, PIN-DK and -DIK showed the same blood level as depilated cases 8 or 24 hours after application of the drugs. The blood level of PIN did not decrease within 10 hours unlike the depilated skin.
