Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis of Tricholomic Acid. IV. Synthesis of DL-threo-α-Amino-3-oxo-5-isoxazolidineacetic Acid
岩崎 英介神谷 高明畑中 千年砂田 裕上柳 次三郎
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1969 年 17 巻 5 号 p. 873-878

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DL-threo-α-Amino-3-oxo-5-isoxazolidineacetic acid, an isomer of tricholomic acid, was synthesized in a 3-step sequence starting from dialkyl N-acyl-β-chloroglutamate. Several isolations have been attempted to separate the threo- and erythro-isomers from their mixture. The threo-isomer was devoid of good taste and flycidal activity which are characteristic of the erythro-isomer.
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© The Pharmaceutical Society of Japan
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